Kaempferol and Its Glycoside Derivatives as Modulators of Etoposide Activity in HL-60 Cells

Kaempferol is a polyphenol found in variety of plants. exerts antitumor properties by affecting proliferation and apoptosis cancer cells. We investigated whether kaempferol its glycoside derivatives—kaempferol 3-O-[(6-O-E-caffeoyl)-?-D-glucopyranosyl-(1?2)]-?-D-galactopyranoside-7-O-?-D-glucuropyranoside (P2), 3-O-[(6-O-E-p-coumaroyl)-?-D-glucopyranosyl-(1?2)]-?-D-galactopyranoside-7-O-?-D-glucuropyranoside (P5) 3-O-[(6-O-E-feruloyl)-?-D-glucopyranosyl-(1?2)]-?-D-galactopyranoside-7-O-?-D-glucuropyranoside (P7), isolated from aerial parts Lens culinaris Medik.—affect the activity etoposide human promyelocytic leukemia (HL-60) analyzed effect derivatives on cytotoxicity, DNA damage, apoptosis, cell cycle progression free radicals induced etoposide. demonstrated that increases sensitivity HL-60 cells to but does not affect this drug. also reduces level generated Unlike kaempferol, some reduce (P2 P7) increase P5) Our results indicate can modulate efficacy way. may have opposite action compared kaempferol.